News Release

Nippon Shinyaku Co., Ltd. has made a public display of
new RNA synthetic technology at the TIDES 2007 conference

Nippon Shinyaku Co., Ltd. (Head Office: Kyoto, Japan; President: Kazuto Hatsuyama) has made a public display of new RNA synthetic technology announced its attendance at the TIDES 2007 conference held in Las Vegas, Nevada, May 20-23.

The presentation includes a description of an innovative RNA synthetic method developed by Nippon Shinyaku Co., Ltd. , , which allows RNA synthesis of higher purity and quality than the conventional method. This technology also enables and the potential of this method for application to the synthesis of very long RNA oligomers which have until now been extremely difficult to synthesize so far and will contribute to the progress of global development of RNA drugs as well as an application to basic research . This technology allows RNA synthesis to be carried out much more simply and easily than by the conventional method. We believe that our new RNA synthetic method is sufficiently practical to become the standard RNA synthetic method, with special application to the synthesis of very long RNA oligomers .

The TIDES 2007 is an international conference where current information on the research, clinical development and production of oligonucleotides and pep tide drugs is presented. About 600 participants were from pharmaceutical industries, bioventure, biomedical companies, universities, and national government agencies in USA , Europe and Asia and got involved in the exchange of information and business negotiation . About 70 companies including several Japanese companies made a public display of their technology and products at booths.

Nippon Shinyaku made the first presentation of RNA technology in EURO TIDES (Hamburg, Germany) last December of which purpose was to enhance the recognition of the technology, while the purpose of the presentation of this time was to publicize the synthetic technology of very long RNA and to develop a global market for RNA related business. Cationic liposome, developed by Nippon Shinyaku as DDS technology necessary for medical application of nucleic acids, was also presented at a workshop .